Warner M R, Warner R L
J Natl Cancer Inst. 1975 Jun;54(6):1369-72. doi: 10.1093/jnci/54.6.1369.
The distribution of mammary dysplasias in 7,12-dimethylbenz[a]anthracene (DMBA)-treated BALB/c female mice differed with respect to the position of mammary gland pairs. The time of life when DMBA was given affected the incidence of lesions more than it did their distribution. Giving neonates injections of 49 mug 17beta-estradiol for the first 5 days of life resulted in increased numbers of dysplasia after DMBA administration at certain ages, but there was no consistent effect on gland-pair distribution of dysplasias at those ages. Possible reasons for differential gland-pair growth and occurrence of dysplasia are discussed.
在经7,12-二甲基苯并[a]蒽（DMBA）处理的BALB/c雌性小鼠中，乳腺发育异常的分布因乳腺对的位置而异。给予DMBA的生命时期对病变发生率的影响大于对其分布的影响。在出生后的前5天给新生小鼠注射49微克的17β-雌二醇，在某些年龄给予DMBA后，发育异常的数量会增加，但对这些年龄发育异常的乳腺对分布没有一致的影响。本文讨论了乳腺对生长差异和发育异常发生的可能原因。
