Dondorp A M, Veenstra J, van der Poll T, Mulder J W, Reiss P
Department of Internal Medicine, Center for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Amsterdam, The Netherlands.
Clin Infect Dis. 1994 Jun;18(6):942-5. doi: 10.1093/clinids/18.6.942.
An AIDS patient with the recalcitrant erythematous desquamating (RED) disorder, a presumed variant of the Staphylococcus aureus toxic shock syndrome that is characterized by relapses, skin involvement, and variable multiple-organ involvement, is described. A strain of S. aureus producing toxic shock syndrome toxin 1 was isolated from the patient, but no antibodies to this exotoxin were detectable before and during the most severe episode of the RED disorder. Levels of cytokines were measured during episodes and at other times. Tumor necrosis factor and interleukin 6 were detectable only during the most severe exacerbation of the disorder; this finding suggests a pathogenetic role for these cytokines.
本文描述了一名患有顽固性红斑脱屑（RED）病症的艾滋病患者，该病症被认为是金黄色葡萄球菌中毒性休克综合征的一种变体，其特征为病情复发、皮肤受累以及多器官受累情况不一。从该患者身上分离出一株产生中毒性休克综合征毒素1的金黄色葡萄球菌菌株，但在RED病症最严重发作之前及发作期间均未检测到针对这种外毒素的抗体。在发作期间及其他时间测量了细胞因子水平。仅在病症最严重恶化期间检测到肿瘤坏死因子和白细胞介素6；这一发现表明这些细胞因子在发病机制中起作用。
