Todorov A A, Siegmund K D, Gu C, Borecki I B, Elston R C
Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Genet Epidemiol. 1997;14(6):909-13. doi: 10.1002/(SICI)1098-2272(1997)14:6<909::AID-GEPI58>3.0.CO;2-Q.
An assumption-free algorithm has been applied to compute the probabilities of all possible identity-by-descent (IBD) configurations when the parents have not been genotyped. These probabilities can be used to determine the amount of information that a particular sibship will bring to a nonparametric linkage analysis. It is shown that the number of possible configurations can be extremely large even when the markers are closely spaced and are rather polymorphic. Further, it is not always possible to reduce this number to a manageable one simply by consideration of the relative probabilities of the configurations.
当父母未进行基因分型时，一种无假设算法已被应用于计算所有可能的同源等位基因（IBD）构型的概率。这些概率可用于确定特定同胞关系将为非参数连锁分析带来的信息量。结果表明，即使标记紧密间隔且具有较高多态性，可能的构型数量也可能极大。此外，仅仅通过考虑构型的相对概率，并不总是能够将这个数量减少到可管理的程度。
