人肾小球裂孔隔膜的等孔亚结构

The isoporous substructure of the human glomerular slit diaphragm.

作者信息

Schneeberger E E, Levey R H, McCluskey R T, Karnovsky M J

出版信息

Kidney Int. 1975 Jul;8(1):48-52. doi: 10.1038/ki.1975.75.

DOI:10.1038/ki.1975.75

Abstract

The substructure of the human glomerular slit diaphragm is examined after perfusion fixation of a human kidney with tannic acid-glutaraldehyde. The present study shows that the substructure of the slit diaphragm in man is very similar to that described in rats and mice, and that the dimensions of the contained pores (50 times 120 A) in the human differ only slightly from those reported for the murine kidney. It is unlikely that rectangular pores of the dimensions of those measured in the human kidney would permit, under physiological conditions, the penetration of significant quantities of serum protein molecules. It is possible, therefore, that the slit diaphragm in the human glomerulus could function as a fine filter for serum proteins, although this remains to be definitely proved.

摘要

在用鞣酸 - 戊二醛灌注固定人肾后，对人肾小球裂孔隔膜的亚结构进行了检查。本研究表明，人类裂孔隔膜的亚结构与在大鼠和小鼠中描述的非常相似，并且人类中所含孔隙（50×120埃）的尺寸与报道的鼠肾中的尺寸仅略有不同。在生理条件下，人肾中测得尺寸的矩形孔隙不太可能允许大量血清蛋白分子穿透。因此，人肾小球中的裂孔隔膜有可能作为血清蛋白的精细过滤器发挥作用，尽管这仍有待确切证明。