Bahnemann R, Bauer C
Department of Toxicology, BASF Aktiengesellschaft, Ludwigshafen, Germany.
Exp Toxicol Pathol. 1994 Mar;46(1):55-62. doi: 10.1016/S0940-2993(11)80017-5.
116 beagle dogs of both sexes were examined for infection with Filaroides hirthi within the framework of several toxicological studies. 98% of the animals demonstrated lung-worm-associated lesions. Most of the macroscopic visible lesions can be subdivided into four groups, representing different histopathological pictures ranging from living worms, different types of granulomatous inflammation to tumorlike lesions. Especially the latter is liable for several misinterpretations in toxicologic studies. This is the first positive evidence of an infection of Beagle dogs with Filaroides hirthi in Germany.
在几项毒理学研究中，对116只雌雄比格犬进行了赫氏丝虫感染检查。98%的动物表现出与肺线虫相关的病变。大多数肉眼可见的病变可分为四组，代表从活虫、不同类型的肉芽肿性炎症到肿瘤样病变的不同组织病理学图像。特别是后者在毒理学研究中容易出现几种误解。这是德国比格犬感染赫氏丝虫的首个阳性证据。
