载脂蛋白E表型与晚发型阿尔茨海默病的关联：基于人群的研究。
Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study.
作者信息
Kuusisto J, Koivisto K, Kervinen K, Mykkänen L, Helkala E L, Vanhanen M, Hänninen T, Pyörälä K, Kesäniemi Y A, Riekkinen P
机构信息
Department of Medicine, Kuopio University Hospital, Finland.
出版信息
BMJ. 1994 Sep 10;309(6955):636-8. doi: 10.1136/bmj.309.6955.636.
Abstract
OBJECTIVE
To determine the association between the e4 allele of apolipoprotein E and Alzheimer's disease in a randomly selected population sample.
DESIGN
Cross sectional population based study.
SUBJECTS
980 people aged 69 to 78 (349 men, 631 women).
SETTING
Population of Kuopio, eastern Finland.
MAIN OUTCOME MEASURES
Presence of e4 allele and diagnosis of Alzheimer's disease by detailed neurological and neurophysiological evaluation.
RESULTS
46 (4.7%) subjects were classified as having probable or possible Alzheimer's disease. The frequency of the apolipoprotein E e4 allele was 0.359 in patients with Alzheimer's disease and 0.165 subjects without dementia (P < 0.0001). The prevalence of Alzheimer's disease was 2.9% in subjects with no e4 alleles, 7.6% in subjects with one e4 allele, and 21.4% in subjects with two e4 alleles of apolipoprotein E.
CONCLUSIONS
Allele e4 of apolipoprotein is associated with Alzheimer's disease in a dose-response fashion in a randomly selected elderly population.
摘要
目的
在一个随机抽取的人群样本中确定载脂蛋白E的e4等位基因与阿尔茨海默病之间的关联。
设计
基于人群的横断面研究。
研究对象
980名年龄在69至78岁之间的人（349名男性，631名女性）。
研究地点
芬兰东部库奥皮奥的人群。
主要观察指标
通过详细的神经学和神经生理学评估确定e4等位基因的存在以及阿尔茨海默病的诊断。
结果
46名（4.7%）受试者被归类为可能患有或疑似患有阿尔茨海默病。阿尔茨海默病患者中载脂蛋白E e4等位基因的频率为0.359，无痴呆症的受试者中该频率为0.165（P < 0.0001）。在没有e4等位基因的受试者中，阿尔茨海默病的患病率为2.9%，在有一个e4等位基因的受试者中为7.6%，在有两个载脂蛋白E e4等位基因的受试者中为21.4%。
结论
在一个随机抽取的老年人群中，载脂蛋白的e4等位基因与阿尔茨海默病呈剂量反应关系。
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