Young R P, Dekker J W, Wordsworth B P, Schou C, Pile K D, Matthiesen F, Rosenberg W M, Bell J I, Hopkin J M, Cookson W O
Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK.
Clin Exp Allergy. 1994 May;24(5):431-9. doi: 10.1111/j.1365-2222.1994.tb00931.x.
In order to test for human histocompatibility leucocyte antigens (HLA) class II restriction of IgE responses, 431 subjects from 83 families were genotyped at the HLA-DR and HLA-DP loci and serotyped for IgE responses to six major allergens from common aero-allergen sources. A possible excess of HLA-DR1 was found in subjects who were responsive to Fel d I compared with those who were not (Odds Ratio (OR) = 2, P = 0.002), and a possible excess of HLA-DR4 was found in subjects responsive to Alt a I (OR = 1.9, P = 0.006). Increased sharing of HLA-DR/DP haplotypes was seen in sibling pairs responding to both allergens. Der p I, Der p II, Phl p V and Can f I were not associated with any definite excess of HLA-DR alleles. No significant correlations were seen with HLA-DP genotype and reactivity to any of the allergens. The results suggest class II HLA restriction is insufficient to account for individual differences in reactivity to common allergens.
为了检测IgE反应的人类组织相容性白细胞抗原（HLA）II类限制，对来自83个家庭的431名受试者进行了HLA - DR和HLA - DP位点的基因分型，并对其针对常见气传变应原来源的六种主要变应原的IgE反应进行了血清分型。与无反应者相比，对猫毛蛋白（Fel d I）有反应的受试者中发现可能存在HLA - DR1过量（优势比（OR）= 2，P = 0.002），对黑麦草花粉变应原（Alt a I）有反应的受试者中发现可能存在HLA - DR4过量（OR = 1.9，P = 0.006）。在对两种变应原均有反应的同胞对中，观察到HLA - DR/DP单倍型的共享增加。屋尘螨变应原1（Der p I）、屋尘螨变应原2（Der p II）、多毛孢属霉菌变应原5（Phl p V）和犬小孢子菌变应原1（Can f I）与任何明确的HLA - DR等位基因过量均无关联。未观察到HLA - DP基因型与对任何变应原的反应性之间存在显著相关性。结果表明，II类HLA限制不足以解释个体对常见变应原反应性的差异。
