Ng K O, Tang G J, Hseu S S, Hsing C H, Lee T Y
Department of Anesthesiology, Veterans General Hospital-Taipei, Taiwan, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1994 Jun;53(6):383-7.
Two patients developed seizure immediately after flumazenil administration that aimed to reverse the prolonged sedative effect of diazepam. The use of benzodiazepine for sedation in ICU may mask valuable information relevant to an ongoing pathological change. The seizure in our patients seemed most likely to result from septic encephalopathy which was unmasked by flumazenil. However, flumazenil has the potential to provoke seizure and should be used with caution.
两名患者在使用氟马西尼以逆转地西泮的长效镇静作用后立即发生癫痫发作。在重症监护病房使用苯二氮䓬类药物进行镇静可能会掩盖与正在发生的病理变化相关的重要信息。我们患者的癫痫发作似乎最有可能是由氟马西尼暴露出来的脓毒症性脑病引起的。然而，氟马西尼有诱发癫痫发作的可能性，应谨慎使用。
