Kuikka J T, Bergström K A, Ahonen A, Länsimies E
Department of Clinical Physiology, Kuopio University Hospital, Finland.
Eur J Nucl Med. 1994 Jan;21(1):53-6. doi: 10.1007/BF00182306.
This report documents the radiation dosimetry of iodine-123 labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane [123I]beta-CIT in humans. The mean absorbed doses for various organs and the effective dose equivalent were estimated from whole-body scans, blood samples and single-photon emission tomography scans acquired up to 22 h after the injection of a known amount of tracer. The basal ganglia, the liver and the lower large intestinal wall received the highest mean absorbed doses of 0.270 mGy/MBq, 0.038 mGy/MBq and 0.034 mGy/MBq, respectively. The effective dose equivalent for adults was estimated using 11 organs and the ICRP-87 radiation dose model and was 0.031 mSv/MBq. The radiation dose to the basal ganglia limits the maximum injected activity of [125I]beta-CIT to 185 MBq for a single study.
本报告记录了碘-123标记的2β-甲氧基羰基-3β-(4-碘苯基)托烷[123I]β-CIT在人体中的辐射剂量学。通过对已知量示踪剂注射后长达22小时内获取的全身扫描、血液样本和单光子发射断层扫描，估算了各个器官的平均吸收剂量和有效剂量当量。基底神经节、肝脏和下大肠壁分别接受了最高的平均吸收剂量，分别为0.270 mGy/MBq、0.038 mGy/MBq和0.034 mGy/MBq。使用11个器官和ICRP-87辐射剂量模型估算的成人均效剂量当量为0.031 mSv/MBq。基底神经节的辐射剂量限制了单次研究中[125I]β-CIT的最大注射活度为185 MBq。
