Uemura T, Namiki T, Kimura A, Yanagisawa T, Minaguchi H
Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Japan.
Horm Res. 1994;41 Suppl 1:7-13. doi: 10.1159/000183936.
In order to know whether gonadotropin-releasing hormone (GnRH)-like substances play a role as local regulators in the ovary, localization of the GnRH receptor, and the effects of GnRH agonist (GnRHa) on the cyclic AMP system in the rat ovary was studied. In addition, effects of GnRH antagonist on the rat ovary and effects of GnRHa on steroidogenesis in the human ovary were also examined. In the rat, localization of the GnRH receptor was observed to change with follicular development, and GnRHa decreased follicle-stimulating-hormone-stimulated cAMP production. On the other hand, GnRH antagonist showed the tendency to promote ovarian function. In the human ovary, GnRHa seemed to inhibit steroidogenesis directly, in vivo and in vitro. These data suggested that GnRH/GnRH-like substances play a role as local regulators in the ovary.
为了了解促性腺激素释放激素（GnRH）样物质是否作为卵巢中的局部调节因子发挥作用，研究了GnRH受体在大鼠卵巢中的定位，以及GnRH激动剂（GnRHa）对大鼠卵巢中环磷酸腺苷（cAMP）系统的影响。此外，还研究了GnRH拮抗剂对大鼠卵巢的影响以及GnRHa对人卵巢类固醇生成的影响。在大鼠中，观察到GnRH受体的定位随卵泡发育而变化，并且GnRHa降低了促卵泡激素刺激的cAMP产生。另一方面，GnRH拮抗剂显示出促进卵巢功能的趋势。在人卵巢中，GnRHa似乎在体内和体外均直接抑制类固醇生成。这些数据表明，GnRH/GnRH样物质作为卵巢中的局部调节因子发挥作用。
