Waring G O, Rodrigues M M, Laibson P R
Surv Ophthalmol. 1975 Jul-Aug;20(1):3-27. doi: 10.1016/0039-6257(75)90034-x.
This paper classifies the abnormalities of the anterior chamber cleavage syndrome (mesodermal dysgenesis of the iris and cornea). The anatomic findings are arranged in a tabular stepladder fashion which builds from simple to more complex combinations, most of which have been previously known by eponyms. There are three groups of anomalies: 1) peripheral, 2) central, and 3) combinations of the two. 1) The peripheral anomalies consist of a prominent Schwalbe's ring, iris strands to Schwalbe's ring, and hypoplasia of the anterior iris stroma. Developmental glaucoma is commonly present. 2) The essential feature of the central anomalies is a defect in the corneal endothelium and Descemet's membrane with an overlying corneal opacity. Additional components include central iridocorneal adhesions, keratolenticular approximation with cataract, and scleralizaiton of the cornea. Chorioretinal anomalies, developmental glaucoma, and systemic malformations may be present. 3) Central and peripheral combinations may exist in the same eye, in both eyes of the same patient, or within the same family.
本文对前房分裂综合征（虹膜和角膜的中胚层发育异常）的异常情况进行了分类。解剖学发现以表格阶梯形式排列，从简单到更复杂的组合，其中大多数以前都有其专属名称。有三组异常情况：1）周边型，2）中央型，3）两者的组合。1）周边异常包括突出的施瓦贝环、连接至施瓦贝环的虹膜条索以及虹膜前基质发育不全。通常伴有发育性青光眼。2）中央异常的基本特征是角膜内皮和后弹力层有缺陷，且上方有角膜混浊。其他成分包括中央虹膜角膜粘连、伴有白内障的角膜晶状体贴近以及角膜巩膜化。可能存在脉络膜视网膜异常、发育性青光眼和全身畸形。3）中央型和周边型组合可能存在于同一只眼睛、同一患者的双眼或同一家族内。
