来自美洲鲎的心脏抑制肽：对神经性心脏的调节

Cardioinhibitory peptides from Limulus polyphemus: modulation of the neurogenic heart.

作者信息

Gaus G, Casaretto M, Stieve H

机构信息

Institut für Biologie II (Zoologie), Aachen, Germany.

出版信息

J Comp Physiol B. 1994;164(3):191-4. doi: 10.1007/BF00354079.

DOI:10.1007/BF00354079

PMID:8089310

Abstract

Four neuropeptides have been isolated and sequenced from acetone extracts of brains of the horseshoe crab Limulus polyphemus. They belong to a newly discovered peptide family in invertebrates. A possible role of the four peptides from Limulus as cardioregulatory neurotransmitters has been tested on the isolated Limulus heart. Three of the peptides (DEGHKMLYFamide, GHSLLHFamide, and PDHHMMYFamide) produce dose-dependent decreases in both amplitude and rate of the heart contractions, whereas DHGNMLYFamide reduces only the amplitude of the heartbeat. All four peptides differ in threshold, potency and duration of their effects.

摘要

从鲎（Limulus polyphemus）大脑的丙酮提取物中分离并测序了四种神经肽。它们属于无脊椎动物中一个新发现的肽家族。已在离体的鲎心脏上测试了来自鲎的这四种肽作为心脏调节神经递质的可能作用。其中三种肽（DEGHKMLYFamide、GHSLLHFamide和PDHHMMYFamide）使心脏收缩的幅度和速率呈剂量依赖性降低，而DHGNMLYFamide仅降低心跳幅度。所有四种肽在作用阈值、效力和持续时间上均有所不同。