Vangheluwe O, Ducasse A, Vaudrey C, Maes B, Delisle M J
Service d'Opthalmologie, CHR Robert-Debré, Reims.
J Fr Ophtalmol. 1994;17(5):331-8.
During a study performed to estimate the prevalence and evolution of ophthalmologic symptoms in Graves' disease, we examined 85 patients suffering from diffuse hyperfunctional goiter, which was recently discovered. Forty-seven of these patients came back to the one year ophthalmologic control examination. The patients classed 1 in the Nospecs at first examination rarely remained in the same class either worsening or ameliorating. The worsening or amelioration were independent from the treatment employed for hyperthyroidism and from the results of this treatment. The patients classed 0 in the Nospecs mostly remained in the same class. The patients in which first examination discovered more severe signs and especially inflammatory signs (eyelid oedema for example) should be carefully followed up.
在一项旨在评估格雷夫斯病眼部症状的患病率及演变情况的研究中，我们检查了85例近期发现患有弥漫性高功能性甲状腺肿的患者。其中47例患者返回接受了为期一年的眼科对照检查。初次检查时在NOSPECS分类中为1级的患者，很少保持在同一级别，病情要么恶化要么改善。病情的恶化或改善与用于治疗甲状腺功能亢进的治疗方法以及该治疗的结果无关。初次检查时在NOSPECS分类中为0级的患者大多保持在同一级别。初次检查发现有更严重体征尤其是炎症体征（例如眼睑水肿）的患者应予以密切随访。
