Kesteloot H, Sasaki S, Xie J, Joossens J V
Department of Epidemiology, School of Public Health, K.U. Leuven, Belgium.
J Hum Hypertens. 1994 Jun;8(6):401-7.
Since 1950 a marked decrease in cerebrovascular mortality has occurred in most Western countries. To evaluate whether changes in the pharmacological treatment of hypertension, introduced during the period observed (1950-87), have influenced this downward trend the linear time-trends over the period considered were calculated. Mass treatment of hypertension at the population level started in the early 1970s. Before this period a marked decrease in cerebrovascular mortality had already occurred. Moreover, the linear time trends were highly significant over the whole period with several correlation coefficients of > 0.98. The decrease in cerebrovascular mortality can best be explained by a decreased salt and saturated fat intake in the populations considered. In several Eastern European countries cerebrovascular mortality has increased. This runs parallel with an increase in all-cause mortality and an increase in ischaemic heart disease mortality and can be explained by the high saturated fat intake of these populations. The data show that important changes in cerebrovascular mortality are also occurring in the older age groups, e.g. 70-74 and 80-84 years. Epidemiological data point towards nutrition as playing an important role in the evolution of cerebrovascular mortality over the period considered.
自1950年以来，大多数西方国家的脑血管疾病死亡率显著下降。为了评估在所观察的时期（1950 - 1987年）引入的高血压药物治疗变化是否影响了这一下降趋势，计算了该时期的线性时间趋势。对高血压的群体治疗始于20世纪70年代初。在此之前，脑血管疾病死亡率已经显著下降。此外，整个时期的线性时间趋势高度显著，几个相关系数> 0.98。在所考虑的人群中，脑血管疾病死亡率的下降最好用盐和饱和脂肪摄入量的减少来解释。在几个东欧国家，脑血管疾病死亡率有所上升。这与全因死亡率的增加以及缺血性心脏病死亡率的增加同时出现，并且可以用这些人群中饱和脂肪的高摄入量来解释。数据表明，在老年人群体（如70 - 74岁和80 - 84岁）中，脑血管疾病死亡率也在发生重要变化。流行病学数据表明，在所考虑的时期内，营养在脑血管疾病死亡率的演变中起着重要作用。
