Filipovich N E, Kirkovskiĭ V V, Mazur L I, Moin V M, Sinilo S B, Lobacheva G A, Berezkina O G
Khirurgiia (Mosk). 1993 May(5):35-8.
The authors studied the character of the therapeutic action of some links of protein metabolism in connection with the use of hemosorption with a biospecific antiprotease hemosorbent "ovosorb" in the complex treatment of 24 patients with diffuse purulent peritonitis of appendicular genesis. It was found that the antiprotease biospecific hemosorbent is marked by high efficacy in the correction of protein metabolism and the consequent systemic disorders in patients with peritonitis of an appendicular genesis. It is shown that "ovosorb" removes selectively from hemocirculation active forms of proteinase of their complexes with inhibitors and, in contrast to carbon sorbents does not possess unspecific sorption of the inhibitors of proteinases and other blood plasms proteins.
作者研究了蛋白质代谢某些环节的治疗作用特点,这与在24例阑尾源性弥漫性化脓性腹膜炎患者的综合治疗中使用生物特异性抗蛋白酶血液吸附剂“卵清蛋白吸附剂”进行血液吸附有关。研究发现,抗蛋白酶生物特异性血液吸附剂在纠正阑尾源性腹膜炎患者的蛋白质代谢及随之而来的全身紊乱方面具有高效性。结果表明,“卵清蛋白吸附剂”能从血液循环中选择性去除蛋白酶与其抑制剂复合物的活性形式,并且与碳吸附剂不同,它对蛋白酶抑制剂及其他血浆蛋白不具有非特异性吸附作用。