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[生物特异性抗蛋白酶血液吸附剂“卵清蛋白吸附剂”在犬弥漫性化脓性腹膜炎和急性坏死性胰腺炎综合治疗中的有效性]

[Effectiveness of the biospecific antiproteinase hemosorbent "Ovosorb" in the comprehensive treatment of diffuse suppurative peritonitis and acute destructive pancreatitis in dogs].

作者信息

Filipovich N E, Kirkovskiĭ V V, Antiperovich O F, Sinilo S B, Lobacheva G A

出版信息

Patol Fiziol Eksp Ter. 1994 Jan-Mar(1):47-9.

PMID:8183598
Abstract

The authors examined the efficacy of the biospecific antiprotease hemosorption Ovosorb containing ovomucoid from duck egg protein as part of polyacrylamide gel, which was used in the multimodality treatment for experimental diffuse pyoperitoneum and acute destructive pancreatitis in dogs. Ovosorb effectively diminished proteasemia, restored the plasma inhibitory potential by eliminating dysproteinemia, suppressed the production of secondary peptide endotoxins. These effects of the hemosorbent promoted the regression of endotoxicosis and the significant reduction in experimental animal deaths.

摘要

作者研究了含有鸭蛋清蛋白类卵黏蛋白的生物特异性抗蛋白酶血液吸附剂Ovosorb作为聚丙烯酰胺凝胶一部分的疗效,该吸附剂用于犬实验性弥漫性脓性腹膜炎和急性坏死性胰腺炎的多模式治疗。Ovosorb有效降低了蛋白酶血症,通过消除蛋白异常血症恢复了血浆抑制潜能,抑制了次级肽内毒素的产生。血液吸附剂的这些作用促进了内毒素血症的消退,并显著降低了实验动物的死亡率。

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