给予1-丙醇的大鼠肝脏、肺和胰腺中脂肪酸丙酯的形成。

Formation of fatty acid propyl esters in liver, lung and pancreas of rats administered 1-propanol.

作者信息

Carlson G P

机构信息

Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1334.

出版信息

Res Commun Chem Pathol Pharmacol. 1993 Jul;81(1):121-4.

PMID:8210685

Abstract

The esterification of fatty acids by ethanol has been associated with a number of adverse reactions. In this study, the administration of 1-propanol (3 ml/kg 24 and 12 hours prior to measurements) to rats resulted in the formation of fatty acid propyl esters of oleic acid, lauric acid and to a lesser extent, palmitic acid and myristic acid. Formation was highest in liver and pancreas and was lower in lung.

摘要

乙醇对脂肪酸的酯化作用与许多不良反应有关。在本研究中，给大鼠注射1-丙醇（在测量前24小时和12小时分别注射3毫升/千克）后，会生成油酸、月桂酸的脂肪酸丙酯，生成的棕榈酸和肉豆蔻酸丙酯较少。肝脏和胰腺中的生成量最高，肺部的生成量较低。