Blumberg J, Block G
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
Nutr Rev. 1994 Jul;52(7):242-5. doi: 10.1111/j.1753-4887.1994.tb01430.x.
The U.S. National Cancer Institute and the Finnish National Public Institute jointly sponsored a large double-blind, placebo-controlled primary-prevention trial to examine the effects of vitamin E and beta-carotene supplementation on reducing the incidence of lung cancers in male smokers, ages 50-69 years. Supplementation did not result in a significant reduction in lung cancer, and a higher incidence of lung cancer was observed in the group receiving beta-carotene. These results should be examined within the context of the population studied before they are cited as definitive.
美国国立癌症研究所和芬兰国家公共卫生研究所联合发起了一项大型双盲、安慰剂对照的一级预防试验，以研究补充维生素E和β-胡萝卜素对降低年龄在50至69岁男性吸烟者肺癌发病率的影响。补充剂并未显著降低肺癌发病率，且在接受β-胡萝卜素的组中观察到肺癌发病率更高。在将这些结果作为定论引用之前，应结合所研究的人群背景进行审视。
