Kwong Y L, Pollock A, Wei D, Lie A K
University Department of Medicine, Queen Mary Hospital, Hong Kong.
Pathology. 1994 Apr;26(2):183-5. doi: 10.1080/00313029400169441.
Bone marrow necrosis is an uncommon histologic finding of malignant diseases at presentation. Clinically it is characterized by pyrexia and severe bone pain, and heralds a poor prognosis if untreated. We report an unusual patient with asymptomatic bone marrow necrosis persisting for 10 mths, a hitherto undescribed length of time for this condition. The diagnosis of Philadelphia chromosome positive acute lymphoblastic leukemia was finally made after multiple bone marrow biopsies.
骨髓坏死是恶性疾病初诊时一种不常见的组织学表现。临床上其特征为发热和严重骨痛，若不治疗则预示预后不良。我们报告了一位不寻常的患者，其无症状性骨髓坏死持续了10个月，这是此种情况迄今未被描述过的时长。经多次骨髓活检后最终确诊为费城染色体阳性急性淋巴细胞白血病。
