Serrou B, Dubois J B
Biomedicine. 1975 Feb 10;23(1):41-5.
Immunological function was studied in 48 patients before, during and after cancer treatment, using cutaneous tests, spontaneous rosettes test and the PHA and PWM lymphocyte stimulation tests. Chemotherapeutic drugs were used individually or in combination for 5 days a month and were preceeded by a cellular synchronization using Vincristine (1 mg/m2/day). When treatment was discontinued, we observed in 30 patients increased rates of spontaneous rosettes and of thymidine uptake. We noticed in several cases that the cutaneous tests became positive even if they were negative before and during treatment. The I.O.P. appeared 5 days after chemotherapy was discontinued and lasted 8 to 12 days. The topography of the neoplasm had no influence on the I.O.P. Failure to manifest I.O.P. is not indicative of a negative response of the tumor to chemotherapy (9 positive responses to chemotherapy out of 18 patients without I.O.P.) But the I.O.P. was a fairly constant feature in patients with positive response to chemotherapy and with favorable prognosis (28/30).
我们使用皮肤试验、自发玫瑰花结试验以及PHA和PWM淋巴细胞刺激试验，对48例癌症患者在癌症治疗前、治疗期间及治疗后进行了免疫功能研究。化疗药物每月单独或联合使用5天，在使用前先用长春新碱（1毫克/平方米/天）进行细胞同步化处理。当治疗停止后，我们观察到30例患者的自发玫瑰花结率和胸腺嘧啶核苷摄取率有所增加。我们注意到，在一些病例中，即使皮肤试验在治疗前和治疗期间为阴性，但在治疗停止后却变为阳性。免疫优化现象（I.O.P.）在化疗停止后5天出现，并持续8至12天。肿瘤的部位对免疫优化现象没有影响。未出现免疫优化现象并不表明肿瘤对化疗反应阴性（18例无免疫优化现象的患者中有9例对化疗有阳性反应）。但是，免疫优化现象在对化疗有阳性反应且预后良好的患者中是一个相当稳定的特征（30例中有28例）。
