Lamers R J, Thelissen G R, Kessels A G, Wouters E F, van Engelshoven J M
Department of Diagnostic Radiology, University Hospital Maastricht, The Netherlands.
Radiology. 1994 Oct;193(1):109-13. doi: 10.1148/radiology.193.1.8090878.
To compare the computed tomographic (CT) lung densitometry results in patients with chronic obstructive pulmonary disease (COPD) and in control subjects (healthy persons).
Spirometrically gated CT sections at 5 cm above and 5 cm below the carina at 90% and 10% vital capacity (VC) were imaged in patients and controls. Various densitometric parameters were derived from the CT data, and results were compared between the two levels of inspiration.
Densitometric results in patients with emphysema were substantially different from those in patients with chronic bronchitis and in controls at 90% and 10% VC. Differences in patients with chronic bronchitis and in controls were not significant at 90% VC but were significant at 10% VC (P < .001). The mean changes in densitometric parameters between 90% and 10% VC were substantially greater in controls than in patients with COPD.
It may be possible to classify lung disease with only two CT sections obtained at the same anatomic level, one at 90% and one at 10% VC, irrespective of the densitometric parameter used.
比较慢性阻塞性肺疾病（COPD）患者与对照者（健康人）的胸部计算机断层扫描（CT）肺密度测定结果。
对患者和对照者在隆突上方5 cm和下方5 cm处进行肺量计门控CT扫描，扫描时分别处于肺活量（VC）的90%和10%。从CT数据中得出各种密度测定参数，并比较两个吸气水平的结果。
在VC为90%和10%时，肺气肿患者的密度测定结果与慢性支气管炎患者及对照者的结果有显著差异。慢性支气管炎患者与对照者在VC为90%时差异不显著，但在VC为10%时差异显著（P < .001）。对照者在VC从90%到10%时密度测定参数的平均变化明显大于COPD患者。
无论使用何种密度测定参数，仅通过在同一解剖水平获取的两个CT层面（一个在VC的90%，另一个在VC的10%）就有可能对肺部疾病进行分类。
