Dhawan D, Goel A
Department of Biophysics, Panjab University, India.
Res Exp Med (Berl). 1994;194(3):203-15. doi: 10.1007/BF02576381.
This study was undertaken to investigate the protective effect of Liv-52, a herbal formulation, on various serum and liver marker enzymes, lipid peroxidation and histological changes in the liver of male albino rats suffering long-term carbon tetrachloride (CCl4) poisoning. It was observed that the activities of serum marker enzymes, hepatic enzymes and NADPH-dependent lipid peroxidation were significantly elevated after treatment with CCl4. However, in rats given Liv-52 at the same time as CCl4, the levels of all the marker enzymes were closer to those found in control animals. A similar trend was seen in the case of lipid peroxidation after Liv-52 treatment. CCl4 alone caused severe liver damage, but when Liv-52 was simultaneously given, there was much less effect on the structure of the organ. Circulating T3 and T4 concentrations were also determined after 6 weeks of simultaneous treatment with Liv-52 and CCl4. Concentrations of T3 were significantly lowered after CCl4 treatment alone, but Liv-52 administration together with CCl4 resulted in maintenance of the T3 activity within normal limits, thus suggesting indirect beneficial effects of Liv-52 on the regulation of thyroid hormone concentrations.
本研究旨在探讨草药配方利维 52 对长期遭受四氯化碳（CCl4）中毒的雄性白化病大鼠血清和肝脏标记酶、脂质过氧化及肝脏组织学变化的保护作用。观察发现，用 CCl4 处理后，血清标记酶、肝酶及 NADPH 依赖性脂质过氧化的活性显著升高。然而，在与 CCl4 同时给予利维 52 的大鼠中，所有标记酶的水平更接近对照动物。利维 52 处理后的脂质过氧化情况也呈现类似趋势。单独使用 CCl4 会导致严重的肝损伤，但同时给予利维 52 时，对器官结构的影响要小得多。在利维 52 和 CCl4 同时处理 6 周后，还测定了循环 T3 和 T4 的浓度。单独用 CCl4 处理后 T3 浓度显著降低，但利维 52 与 CCl4 一起给药可使 T3 活性维持在正常范围内，这表明利维 52 对甲状腺激素浓度的调节具有间接有益作用。
