Goel A, Dhawan D, Kheruka S
Department of Biophysics, Panjab University, Chandigarh, India.
Biol Trace Elem Res. 1994 Apr-May;41(1-2):59-68. doi: 10.1007/BF02917217.
Circulating tri-iodothyronine (T3) and thyroxine (T4) concentrations were determined after 6 wk of zinc treatment to carbontetrachloride (CCl4) intoxicated male albino rats. Concentrations of T3 were observed to be significantly depressed following CCl4 treatment alone. On the contrary, no significant change was noticed in the concentrations of T4 when compared to controls. However, zinc administration to hepatotoxic animals resulted in restoring the T3 activity to within normal limits, thus indicating the indirect effects of zinc on the regulation of thyroid hormone concentrations. The activities of all the serum and hepatic marker enzymes were found to be significantly elevated following CCl4 treatment. However, following zinc supplementation to these intoxicated animals, the levels of the marker enzymes decreased significantly when compared to the CCl4-treated animals. A similar trend was seen in the case of lipid peroxidation following zinc treatment.
对四氯化碳（CCl4）中毒的雄性白化病大鼠进行锌治疗6周后，测定其循环中三碘甲状腺原氨酸（T3）和甲状腺素（T4）的浓度。单独用CCl4处理后，观察到T3浓度显著降低。相反，与对照组相比，T4浓度未发现显著变化。然而，给肝毒性动物施用锌可使T3活性恢复到正常范围内，从而表明锌对甲状腺激素浓度调节的间接作用。CCl4处理后，所有血清和肝脏标记酶的活性均显著升高。然而，给这些中毒动物补充锌后，与CCl4处理的动物相比，标记酶的水平显著降低。锌处理后脂质过氧化情况也呈现类似趋势。
