Thabrew M I, Emerole G O, Subbarao V V
Toxicol Lett. 1982 Dec;14(3-4):183-8. doi: 10.1016/0378-4274(82)90049-2.
The effects of the hepatotonic Liv-52 on carbon tetrachloride (CCl4)-induced changes in the activities of the microsomal enzymes, aniline hydroxylase, p-aminopyrine N-demethylase and aryl hydrocarbon hydroxylase (AHH), have been investigated. Treatment with Liv-52 (before or after CCl4 administration) markedly decreased, the CCl4-mediated reduction in aniline hydrochloride and p-aminopyrine N-demethylase activities, although the decrease in AHH activity could not be prevented. Kinetic studies showed that the effect of Liv-52 was not due to an alteration in the Km values of the enzymes. The possible mechanism by which Liv-52 moderated the CCl4-induced changes in the microsomal drug-metabolizing enzymes is discussed.
已对具有保肝作用的利维 52（Liv-52）对四氯化碳（CCl4）诱导的微粒体酶、苯胺羟化酶、对氨基苯丙胺 N-脱甲基酶和芳烃羟化酶（AHH）活性变化的影响进行了研究。用利维 52 治疗（在给予 CCl4 之前或之后）显著降低了 CCl4 介导的盐酸苯胺和对氨基苯丙胺 N-脱甲基酶活性的降低，尽管无法阻止 AHH 活性的降低。动力学研究表明，利维 52 的作用并非由于酶的 Km 值改变所致。本文讨论了利维 52 调节 CCl4 诱导的微粒体药物代谢酶变化的可能机制。
