丙硫氧嘧啶所致肝毒性
Hepatotoxicity from propylthiouracil.
作者信息
Westphal S A
机构信息
Department of Medicine, Maricopa Medical Center, Phoenix, AZ 85008.
出版信息
South Med J. 1994 Sep;87(9):943-7. doi: 10.1097/00007611-199409000-00018.
Propylthiouracil is a drug used commonly to treat hyperthyroidism. Among its side effects, hepatotoxicity is one of the rarest but one of the most serious. This complication may be due to an immune mechanism. However, particular risk factors associated with the development of hepatotoxicity are not known, and its occurrence is unpredictable. I report a case of acute hepatitis developing during propylthiouracil therapy for Graves' disease and review the literature related to this problem.
丙硫氧嘧啶是一种常用于治疗甲状腺功能亢进症的药物。在其副作用中，肝毒性是最罕见但最严重的副作用之一。这种并发症可能是由免疫机制引起的。然而，与肝毒性发生相关的特定风险因素尚不清楚，其发生也不可预测。我报告一例在丙硫氧嘧啶治疗格雷夫斯病期间发生急性肝炎的病例，并回顾与此问题相关的文献。
Zotero 插件