Lock D R, Sthoeger Z M
Endocrinology Unit, Kaplan Hospital, Rehovot, Israel.
J Clin Gastroenterol. 1997 Jun;24(4):267-9. doi: 10.1097/00004836-199706000-00020.
We report a case of propylthiouracil (PTU)-induced cholestatic hepatotoxicity in Graves' disease that developed 1 day after beginning PTU. After clinical recover, liver abnormalities persisted for 5 years. Percutaneous liver biopsy and the eventual normalization of enzyme levels excluded permanent liver damage as a result of PTU therapy. Thus prolonged elevation of serum enzymes is consistent with the diagnosis of PTU-induced hepatotoxicity, which may recover completely.
我们报告1例格雷夫斯病患者在开始服用丙硫氧嘧啶（PTU）1天后发生PTU诱导的胆汁淤积性肝毒性。临床恢复后，肝脏异常持续了5年。经皮肝活检及酶水平最终恢复正常排除了PTU治疗导致的永久性肝损伤。因此，血清酶的长期升高符合PTU诱导的肝毒性诊断，这种肝毒性可能会完全恢复。
