Pliska V
ETH Zürich Department of Animal Science, Switzerland.
Trends Pharmacol Sci. 1994 Jun;15(6):178-81. doi: 10.1016/0165-6147(94)90145-7.
Over a broad dose (or concentration) range, dose-response relationships frequently display a bell-shaped form. Mechanisms leading to this phenomenon may be manifold, but so far they have not been adequately identified. In this article, Vladimir Pliska discusses two models that are based on multiple-state cell-signaling pathways and enable an estimate of generally applicable descriptors. These can be used for expression of drug potency and for similar purposes.
在很宽的剂量（或浓度）范围内，剂量-反应关系常常呈现钟形。导致这种现象的机制可能多种多样，但迄今为止尚未得到充分确定。在本文中，弗拉基米尔·普利什卡讨论了基于多状态细胞信号通路的两种模型，这些模型能够估计普遍适用的描述符。这些描述符可用于表达药物效力及类似目的。
