Lacombe M J
C R Acad Hebd Seances Acad Sci D. 1975 Feb 24;280(8):1039-41.
The observation of a coagulation defect which has been observed in an adult French woman is reported. This deficiency which induces no bleeding tendency is characterized by a considerable lengthening of the activated Partial Thromboplastin Time and an abnormality of the fibrinolysis activation. Circulating anticoagulant is absent. The levels of HF, PTA, AHF, PTC are normal and mutual correction with Fletcher factor deficient plasma is obtained. This result leads to the conclusion that patient's plasma is dificient in a hitherto undescribed coagulation factor. This factor seems to interfere, in vitro process, at the level of glass activation, and after the activation of Hageman factor.
报告了一名成年法国女性出现凝血缺陷的观察情况。这种无出血倾向的缺陷表现为活化部分凝血活酶时间显著延长以及纤维蛋白溶解活化异常。未发现循环抗凝物质。HF、PTA、AHF、PTC水平正常，且与 Fletcher 因子缺乏血浆相互校正。这一结果得出结论，患者血浆中缺乏一种迄今未描述的凝血因子。该因子似乎在体外过程中，在玻璃活化水平以及接触因子活化后发挥干扰作用。
