Koch J, Pedersen H D, Jensen A L, Flagstad A, Poulsen K, Bie P
Small Animal Hospital, Department of Clinical Studies, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark.
Zentralbl Veterinarmed A. 1994 Mar;41(2):121-7. doi: 10.1111/j.1439-0442.1994.tb00074.x.
The purpose of the present study was to quantify some of the short term responses of the renin-angiotensin system (RAS) to a recommended dosage of the angiotensin-converting enzyme inhibitor enalapril in clinically healthy dogs fed a normal-sodium and a low-sodium diet. A single dose of enalapril (0.5 mg/kg PO) was given to eight clinically healthy male Beagle dogs after a period where the dogs were fed a normal-sodium diet and low-sodium diet, respectively. Serum angiotensin-converting enzyme activity (ACE), plasma renin activity (PRA), plasma aldosterone concentration (PAC), and plasma atrial natriuretic peptide (ANP) concentration were measured during the following twenty-four hour period. The data indicate that enalapril induced a potent blockade of the renin-angiotensin system (RAS) for at least twenty-four hour. Specifically, enalapril during low-sodium diet elicited an exaggerated increase in PRA and a diminished decrease in ACE and ANP when compared to the results of the drug during normal-sodium diet. Long term controlled studies of enalapril in dogs with congestive heart failure (CHF) are warranted in order to determine the duration of action and optimal dose of enalapril.
本研究的目的是量化肾素-血管紧张素系统（RAS）对推荐剂量的血管紧张素转换酶抑制剂依那普利的一些短期反应，该研究以喂食正常钠饮食和低钠饮食的临床健康犬为对象。在分别喂食正常钠饮食和低钠饮食一段时间后，对八只临床健康的雄性比格犬给予单剂量的依那普利（0.5mg/kg口服）。在接下来的24小时内测量血清血管紧张素转换酶活性（ACE）、血浆肾素活性（PRA）、血浆醛固酮浓度（PAC）和血浆心钠素（ANP）浓度。数据表明依那普利至少在24小时内对肾素-血管紧张素系统（RAS）产生了有效的阻断作用。具体而言，与喂食正常钠饮食时药物的结果相比，喂食低钠饮食时依那普利引起PRA过度升高，而ACE和ANP的降低减弱。有必要对患有充血性心力衰竭（CHF）的犬进行依那普利的长期对照研究，以确定依那普利的作用持续时间和最佳剂量。
