大鼠口服单剂量7,12 - 二甲基- 1,2 - 苯并(a)蒽后垂体血清素水平的扰动
Perturbations of the levels of hypophyseal serotonin induced by oral administration of a single dose of 7, 12-dimethyl 1-2 benz(a)anthracene in rats.
作者信息
Guerinot F, Janiaud P, Le Maout M, Aubert C, Bohuon C
出版信息
C R Acad Hebd Seances Acad Sci D. 1975 Jul 21;281(2-3):211-4.
PMID:809206
Abstract
Pituitary serotonin was estimated by fluorescence technique in rats fed with DMBA at 30 days, 60 days or 90 days age. In the rats most receptive to this carcinogen, serotonin was found to be decreased to 40% of control values, for the 8 days period studied. A possible mechanism leading to hormonal unbalance is proposed.
摘要
采用荧光技术对30日龄、60日龄或90日龄喂食二甲基苯蒽（DMBA）的大鼠垂体中的血清素进行了测定。在对这种致癌物最敏感的大鼠中，在所研究的8天期间，血清素被发现降至对照值的40%。本文提出了一种导致激素失衡的可能机制。
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