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[9,12-二甲基-1,2-苯并蒽给药对大鼠发情周期血浆及垂体催乳素水平的影响]

[Effect of the administration of 9,12 dimethyl-1,2 benzanthracene on the plasma and pituitary levels of prolactin in rats during the estrous cycle].

作者信息

Valero D, Blanquet P, Aubert C

出版信息

C R Acad Hebd Seances Acad Sci D. 1976 Mar 22;282(12):1179-82.

PMID:819159
Abstract

Plasma determination of prolactin in the Rat after administration of DMBA has shown that the hormonal peak was practically suppressed whereas in the pituitary the concentration of prolactin 4 was much higher than the one found in the controls whatever the oestral state. The experiments reported concerning plasma and pituitary, permit us to propose several possible mechanisms for the carcinogenic action of DMBA.

摘要

对给予二甲基苯蒽（DMBA）后的大鼠进行血浆催乳素测定，结果显示激素峰值实际上受到了抑制，而无论处于何种发情状态，垂体中催乳素4的浓度都远高于对照组。关于血浆和垂体的实验报道，使我们能够提出几种二甲基苯蒽致癌作用的可能机制。

相似文献

1
[Effect of the administration of 9,12 dimethyl-1,2 benzanthracene on the plasma and pituitary levels of prolactin in rats during the estrous cycle].[9,12-二甲基-1,2-苯并蒽给药对大鼠发情周期血浆及垂体催乳素水平的影响]
C R Acad Hebd Seances Acad Sci D. 1976 Mar 22;282(12):1179-82.
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Changes in FSH, LH and prolactin secretion during estrous cycle in rats.
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[Histological evidence of 'estrogenic properties' of 7--12 dimethylbenz(a)anthracene (author's transl)].
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Endocrinologic milieu and susceptibility of the rat mammary gland to carcinogenesis.大鼠乳腺的内分泌环境及其对致癌作用的易感性。
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