Aylward E H, Reiss A, Barta P E, Tien A, Han W, Lee J, Pearlson G D
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287-7362.
Am J Psychiatry. 1994 Oct;151(10):1448-52. doi: 10.1176/ajp.151.10.1448.
Previous research has yielded conflicting results regarding the hypothesis that structural abnormalities of the cerebellar vermis and other posterior fossa structures are associated with schizophrenia. The purpose of this study was to apply techniques of measuring posterior fossa structures from magnetic resonance imaging scans that have proven reliable in identifying structural abnormalities in other patient populations.
Midsagittal areas of cerebellar vermis and its subsections (anterior vermis, lobules VI-VII, and lobules VIII-X), brainstem (pons, medulla, and midbrain), and fourth ventricle, as well as intracranial area and cortical area, were measured. Subjects included 36 schizophrenic patients and 51 normal comparison subjects. Groups were matched on age, sex, race, and family socioeconomic status.
No significant group differences were detected for any posterior fossa structure. When corrected for intracranial area, fourth ventricle area was significantly larger in patients than in the comparison group. Fourth ventricle area was not, however, correlated with any measures of symptom severity.
The size of posterior fossa structures is not abnormal in schizophrenia.
关于小脑蚓部及其他后颅窝结构的结构异常与精神分裂症相关这一假说，先前的研究结果相互矛盾。本研究的目的是应用磁共振成像扫描测量后颅窝结构的技术，该技术已被证明在识别其他患者群体的结构异常方面是可靠的。
测量小脑蚓部及其各节段（蚓前部、小叶VI - VII和小叶VIII - X）、脑干（脑桥、延髓和中脑）、第四脑室的矢状面面积，以及颅内面积和皮质面积。受试者包括36例精神分裂症患者和51例正常对照受试者。两组在年龄、性别、种族和家庭社会经济地位方面相匹配。
未检测到任何后颅窝结构存在显著的组间差异。校正颅内面积后，患者的第四脑室面积显著大于对照组。然而，第四脑室面积与任何症状严重程度指标均无相关性。
精神分裂症患者后颅窝结构的大小并无异常。
