Aylward E H, Reiss A
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
J Psychiatr Res. 1991;25(4):159-68. doi: 10.1016/0022-3956(91)90020-b.
This study was undertaken to determine the extent to which area measures of posterior fossa structures can be used confidently to represent structure volumes. MRI scans were obtained from three groups: fragile X males, males with other developmental disabilities, and males with normal IQ. The areas of the midbrain, pons, medulla, cerebellar vermis, and fourth ventricle were measured in midsagittal sections. Volumes of midbrain, pons, medulla, cerebellum, fourth ventricle, and third ventricle were obtained by measuring these structures in contiguous axial slices. In addition, the largest axial area for each structure was identified. Analysis revealed that midsagittal area measures for pons, medulla, and fourth ventricle were significantly correlated with structure volumes, and that all of the largest axial area measures were significantly correlated with structure volumes. However, only the midsagittal area measure of fourth ventricle and the largest axial area measures of fourth ventricle and cerebellum were correlated with volume measures with an r of .80 of greater. Results of this study suggest that area measures may not accurately represent three-dimensional structure size.
本研究旨在确定后颅窝结构的面积测量在多大程度上能够可靠地用于代表结构体积。对三组男性进行了MRI扫描：脆性X综合征男性、患有其他发育障碍的男性以及智商正常的男性。在正中矢状切面测量中脑、脑桥、延髓、小脑蚓部和第四脑室的面积。通过在连续轴位切片中测量这些结构来获取中脑、脑桥、延髓、小脑、第四脑室和第三脑室的体积。此外，确定了每个结构的最大轴位面积。分析表明，脑桥、延髓和第四脑室的正中矢状面积测量与结构体积显著相关，并且所有最大轴位面积测量与结构体积均显著相关。然而，只有第四脑室的正中矢状面积测量以及第四脑室和小脑的最大轴位面积测量与体积测量的相关系数r大于0.80。本研究结果表明，面积测量可能无法准确代表三维结构大小。
