子宫内可卡因、铅和尼古丁暴露与胎儿生长
Intrauterine cocaine, lead, and nicotine exposure and fetal growth.
作者信息
Neuspiel D R, Markowitz M, Drucker E
机构信息
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY.
出版信息
Am J Public Health. 1994 Sep;84(9):1492-5. doi: 10.2105/ajph.84.9.1492.
Abstract
Intrauterine tobacco, lead, and cocaine exposure often co-occur and may affect fetal growth and development, yet studies of gestational cocaine effects have not adequately measured lead or tobacco. In this anonymous survey, blood lead and urine cotinine levels were determined and mothers were queried about tobacco use. Eighteen cocaine-exposed mother-infant dyads had higher lead and cotinine levels than 46 random nonexposed dyads, regardless of reported cigarette smoking. Crude growth decrements in cocaine-exposed newborns were attenuated after control for lead and cotinine. Future studies of gestational cocaine effects should measure other toxic exposures with more precision.
摘要
子宫内烟草、铅和可卡因暴露常常同时发生，可能会影响胎儿生长发育，但关于孕期可卡因影响的研究尚未充分测量铅或烟草暴露情况。在这项匿名调查中，测定了血铅和尿可替宁水平，并询问母亲们的烟草使用情况。18对可卡因暴露母婴二元组的铅和可替宁水平高于46对随机抽取的未暴露二元组，无论其报告的吸烟情况如何。在控制铅和可替宁因素后，可卡因暴露新生儿的原始生长指标下降情况有所减弱。未来关于孕期可卡因影响的研究应更精确地测量其他有毒物质暴露情况。
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