Wolff J, Carl P, Hansen P B, Høgskilde S, Christensen M S, Sørensen M B
Department of Anesthesiology, Bispebjerg Hospital, University of Copenhagen, Denmark.
Anesthesiology. 1994 Sep;81(3):623-7. doi: 10.1097/00000542-199409000-00015.
Eltanolone is a new steroid anesthetic agent that may prove to be useful in clinical practice. The aim of the present study was to evaluate the effects of eltanolone on cerebral blood flow (CBF) and metabolism in healthy volunteers.
In a randomized cross-over study, eight subjects received intravenous eltanolone 0.6 mg/kg or its vehicle. CBF was measured with the intravenous xenon 133 technique before and 2 and 30 min after administration of eltanolone or vehicle. Cerebral metabolic rate for oxygen (CMRO2) was calculated as the product of the measured cerebral arteriovenous oxygen content difference and the blood flow.
CBF decreased from a baseline value of 64 +/- 4 (mean +/- SD) to 42 +/- 6 ml.100 g-1.min-1 at 2 min after administration of eltanolone and only 4% after vehicle. Cerebral oxygen consumption was 4.1 +/- 0.4 ml.100 g-1.min-1 at baseline and decreased to 2.7 +/- 0.6 at 2 min after eltanolone, whereas metabolism did not change significantly after administration of vehicle. At 30 min CBF and Cerebral metabolic rate for oxygen were 16 and 10% less than baseline values, respectively. Coupling between CBF and Cerebral metabolic rate for oxygen was preserved at all measurements. After administration of eltanolone a significant decrease in mean arterial blood pressure of 6 mmHg and a period of hypoventilation were observed. This did not occur after injection of vehicle.
Eltanolone was shown to reduce cerebral oxygen consumption and blood flow in healthy volunteers. Coupling between metabolism and flow was preserved.
依他诺龙是一种新型甾体麻醉剂，可能在临床实践中有用。本研究的目的是评估依他诺龙对健康志愿者脑血流量（CBF）和代谢的影响。
在一项随机交叉研究中，8名受试者接受了0.6mg/kg静脉注射依他诺龙或其赋形剂。在注射依他诺龙或赋形剂前、注射后2分钟和30分钟，采用静脉注射氙133技术测量CBF。脑氧代谢率（CMRO2）通过测量的脑动静脉氧含量差与血流量的乘积计算得出。
注射依他诺龙后2分钟，CBF从基线值64±4（平均值±标准差）降至42±6ml·100g-1·min-1，注射赋形剂后仅下降4%。基线时脑氧耗量为4.1±0.4ml·100g-1·min-1，注射依他诺龙后2分钟降至2.7±0.6，而注射赋形剂后代谢无显著变化。30分钟时，CBF和脑氧代谢率分别比基线值低16%和10%。所有测量中CBF与脑氧代谢率之间的耦合均得以保留。注射依他诺龙后，平均动脉血压显著下降6mmHg，并出现一段时间的通气不足。注射赋形剂后未出现这种情况。
依他诺龙可降低健康志愿者的脑氧耗量和血流量。代谢与血流之间的耦合得以保留。
