氨茶碱对早产儿脑干听觉诱发电位的影响。
Effect of aminophylline on brain stem auditory evoked potentials in preterm infants.
作者信息
Chen Y J, Liou C S, Tsai C H, Yeh T F
机构信息
Department of Paediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1994 Jul;71(1):F20-3. doi: 10.1136/fn.71.1.f20.
To determine the neurophysiological effects of aminophylline on apnoea of prematurity, the brain stem auditory evoked potentials (BAEPs) of 30 apnoeic infants and 34 age matched controls were evaluated and compared. After six days of treatment with aminophylline, the brain stem conduction time (interpeak latency of I-V) in apnoeic infants decreased compared with controls of a similar postconceptional age. The mean latencies of the peaks and interpeaks of all waves except wave I were significantly lower in the apnoeic infants after than before receiving aminophylline. No significant differences were found in the latencies of BAEPs between the apnoeic infants who responded and those who did not respond to aminophylline treatment, however. These results suggest that aminophylline may enhance conduction along central auditory pathways and stimulate the regulatory effect on the respiratory centre of the brain stem.
为确定氨茶碱对早产儿呼吸暂停的神经生理作用，对30例呼吸暂停婴儿和34例年龄匹配的对照婴儿的脑干听觉诱发电位（BAEPs）进行了评估和比较。在接受氨茶碱治疗6天后，与孕龄相似的对照婴儿相比，呼吸暂停婴儿的脑干传导时间（I-V峰间潜伏期）缩短。呼吸暂停婴儿在接受氨茶碱治疗后，除I波外，所有波峰和峰间的平均潜伏期均显著低于治疗前。然而，对氨茶碱治疗有反应和无反应的呼吸暂停婴儿之间，BAEPs潜伏期未发现显著差异。这些结果表明，氨茶碱可能增强沿中枢听觉通路的传导，并刺激对脑干呼吸中枢的调节作用。
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