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直肠用氨茶碱治疗早产儿呼吸暂停

Rectal aminophylline in the management of apnoea of prematurity.

作者信息

Lyon A J, McIntosh N

出版信息

Arch Dis Child. 1985 Jan;60(1):38-41. doi: 10.1136/adc.60.1.38.

DOI:10.1136/adc.60.1.38
PMID:3970566
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1777079/
Abstract

Rectal suppositories as an alternative to intravenous aminophylline in the management of recurrent apnoea were studied in 41 preterm infants of mean gestation 28.3 weeks and mean birthweight 1176 g. Therapeutic blood concentrations were obtained two hours after a rectal loading dose of 10 mg/kg, with steady concentrations and maximum reduction in apnoeic episodes (from a mean of 0.5 per hour to 0.09 per hour) within 24 hours on a maintenance dose of 10 mg/kg/day. There was good correlation between the rectal dose and the plasma theophylline concentration. Several infants showed a significant reduction in Pco2 when treated with aminophylline. Side effects were related to the plasma theophylline concentration and were not seen at concentrations less than 14 mg/l.

摘要

在41例平均孕周28.3周、平均出生体重1176克的早产婴儿中，研究了直肠栓剂作为静脉注射氨茶碱治疗反复呼吸暂停的替代方法。在给予10mg/kg的直肠负荷剂量两小时后，达到治疗血药浓度，在维持剂量为10mg/kg/天的情况下，24小时内血药浓度稳定，呼吸暂停发作次数最大程度减少（从平均每小时0.5次降至每小时0.09次）。直肠剂量与血浆茶碱浓度之间存在良好的相关性。几名婴儿在接受氨茶碱治疗时，Pco2显著降低。副作用与血浆茶碱浓度有关，在浓度低于14mg/l时未出现。

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引用本文的文献

1
Effect of aminophylline on cerebral haemodynamics and oxidative metabolism in premature infants.
Eur J Pediatr. 1994 Feb;153(2):123-8. doi: 10.1007/BF01959223.
2
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Clin Pharmacokinet. 1991 Aug;21(2):110-28. doi: 10.2165/00003088-199121020-00003.

本文引用的文献

1
Severe toxic effects from aminophylline and theophylline suppositories in children.氨茶碱和茶碱栓剂对儿童的严重毒性作用。
J Am Med Assoc. 1956 Jun 23;161(8):693-7. doi: 10.1001/jama.1956.02970080023008.
2
Aminophylline poisoning.氨茶碱中毒
Pediatrics. 1954 Nov;14(5):528-32.
3
Apnoeic attacks in the newborn treated with aminophylline.用氨茶碱治疗新生儿呼吸暂停发作。
Arch Dis Child. 1973 May;48(5):404-6. doi: 10.1136/adc.48.5.404.
4
Treatment of apnea of prematurity with aminophylline.用氨茶碱治疗早产儿呼吸暂停。
Pediatrics. 1976 Sep;58(3):335-9.
5
Pharmacokinetic aspects of theophylline in premature newborns.氨茶碱在早产新生儿中的药代动力学研究
N Engl J Med. 1976 Aug 19;295(8):413-6. doi: 10.1056/NEJM197608192950803.
6
Dosage schedule for intravenous aminophylline in apnoea of prematurity, based on pharmacokinetic studies.基于药代动力学研究的早产儿呼吸暂停静脉注射氨茶碱的给药方案。
Arch Dis Child. 1979 Mar;54(3):190-3. doi: 10.1136/adc.54.3.190.
7
Prevention of apnea and bradycardia in low-birthweight infants.预防低体重儿呼吸暂停和心动过缓。
Pediatrics. 1975 May;55(5):589-94.
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Physiologic changes induced by theophylline in the treatment of apnea in preterm infants.
J Pediatr. 1978 Jan;92(1):91-5. doi: 10.1016/s0022-3476(78)80084-5.

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