海藻酸钠对宫颈出血止血作用的研究

A study on the hemostatic effect of sodium alginate on uterocervical hemorrhage.

作者信息

Nishiya M, Hareyama H, Makinoda S, Fujimoto S

机构信息

Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Sapporo, Japan.

出版信息

Asia Oceania J Obstet Gynaecol. 1994 Jun;20(2):203-8. doi: 10.1111/j.1447-0756.1994.tb00451.x.

DOI:10.1111/j.1447-0756.1994.tb00451.x

PMID:8092969

Abstract

We examined a sodium alginate preparation (Alto) to determine its hemostatic effect, in comparison with other topical drugs, on hemorrhages in the uterocervical area. A total of 149 patients with hemorrhage from cervical erosion or after-treatment bleeding of the cervix uteri were subjects in this trial, and 84 (79%) of 106 patients treated with this preparation experienced a hemostatic effect. A significant positive correlation (p < 0.001) was noted between the degree of tissue adhesiveness and the hemostatic effect in all the drugs tested. As for the tissue adhesiveness, Alto was significantly more favorable (p < 0.001) than both Thrombin and Francetin T powder. Because Alto was softened by tissue moisture, its topical adhesiveness could be increased, which suggested that Alto was superior in hemostasis.

摘要

我们研究了一种海藻酸钠制剂（Alto），以确定其与其他局部用药相比，对子宫颈区域出血的止血效果。本试验共有149例宫颈糜烂出血或子宫颈治疗后出血的患者作为研究对象，使用该制剂治疗的106例患者中有84例（79%）出现了止血效果。在所有测试药物中，组织黏附程度与止血效果之间存在显著正相关（p < 0.001）。就组织黏附性而言，Alto明显优于凝血酶和法安明T粉（p < 0.001）。由于Alto会因组织水分而软化，其局部黏附性会增强，这表明Alto在止血方面更具优势。