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使用型特异性包膜肽检测非洲人中的HTLV-I和HTLV-II感染。

Detection of HTLV-I and HTLV-II infection in Africans using type-specific envelope peptides.

作者信息

Goubau P, Desmyter J, Swanson P, Reynders M, Shih J, Surmont I, Kazadi K, Lee H

机构信息

Department of Microbiology, Rega Institute, Leuven, Belgium.

出版信息

J Med Virol. 1993 Jan;39(1):28-32. doi: 10.1002/jmv.1890390107.

DOI:10.1002/jmv.1890390107
PMID:8093712
Abstract

Antibodies to HTLV were determined in 4,630 black African individuals from Zaire, Ghana and South Africa; 185 (4%) were confirmed as seropositive. Seroprevalance was 0.2% in a group of South African women, 0.9% among Ghanaian refugees in Belgium and from less than 1% to over 15% in various sites and populations in Zaire. With the use of HTLV-I and HTLV-II type-specific envelope peptides, 93% of confirmed HTLV seropositives were classified as HTLV-I. Five persons from the Haut Zaire region had HTLV-II serological reactivities, suggesting the presence of HTLV-II or a related retrovirus in central Africa. A cluster of HTLV-I-like indeterminate western blot patterns lacking anti-p24 antibody was found in Bas Zaire.

摘要

对来自扎伊尔、加纳和南非的4630名非洲黑人个体进行了抗人嗜T淋巴细胞病毒(HTLV)抗体检测;其中185人(4%)被确认为血清阳性。在一组南非女性中血清阳性率为0.2%,在比利时的加纳难民中为0.9%,而在扎伊尔的不同地点和人群中,血清阳性率从不到1%到超过15%不等。使用HTLV - I和HTLV - II型特异性包膜肽,93%确诊的HTLV血清阳性者被归类为HTLV - I。来自上扎伊尔地区的5人有HTLV - II血清学反应,提示在中非存在HTLV - II或一种相关逆转录病毒。在下扎伊尔发现了一组缺乏抗p24抗体的类似HTLV - I的不确定免疫印迹模式。

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