Ferguson M M
Department of Oral Medicine and Oral Surgery, University of Otago, New Zealand.
Oral Surg Oral Med Oral Pathol. 1993 Feb;75(2):186-91. doi: 10.1016/0030-4220(93)90092-i.
Sialagogues constitute an important component in the management of salivary gland dysfunction. Of the pharmacologic agents available, pilocarpine has been used extensively over the last century. Many clinical trials have documented the efficacy of this alkaloid, with doses that range from 1 to 15 mg normally taken four times a day. There is considerable individual variation in response although it is usually possible, in the presence of sufficient responsive exocrine tissue, to establish a therapeutic regimen that promotes increased salivation without significant side effects.
催涎剂是唾液腺功能障碍管理中的一个重要组成部分。在现有的药物制剂中，毛果芸香碱在过去一个世纪中得到了广泛应用。许多临床试验都证明了这种生物碱的疗效，通常剂量为1至15毫克，每天服用四次。尽管在有足够反应性外分泌组织的情况下，通常有可能建立一种能促进唾液分泌增加且无明显副作用的治疗方案，但个体反应存在相当大的差异。
