Fox P C, van der Ven P F, Baum B J, Mandel I D
Oral Surg Oral Med Oral Pathol. 1986 Mar;61(3):243-8. doi: 10.1016/0030-4220(86)90369-5.
A double-blind placebo-controlled study was conducted to evaluate the efficacy of orally administered pilocarpine in treating oral dryness caused by salivary gland hypofunction. At low dosages, pilocarpine increased the production of saliva by parotid and submandibular and/or sublingual glands and relieved the sensation of oral dryness. The quantity and composition of pilocarpine-stimulated secretions were similar to saliva produced in response to gustatory stimulation with citrate. In appropriate patients, pilocarpine is a safe, easily administered, effective therapy to relieve xerostomia by increasing natural salivary function.
进行了一项双盲安慰剂对照研究，以评估口服毛果芸香碱治疗唾液腺功能减退引起的口腔干燥的疗效。低剂量时，毛果芸香碱可增加腮腺、下颌下腺和/或舌下腺的唾液分泌，并缓解口腔干燥感。毛果芸香碱刺激分泌的量和成分与柠檬酸味觉刺激产生的唾液相似。对于合适的患者，毛果芸香碱是一种安全、易于给药、有效的治疗方法，可通过增加自然唾液功能来缓解口干症。
