Karson C N, Lyon N, Amick R, Bracha H S, Guggenheim F G
Department of Psychiatry, University of Arkansas for Medical Sciences.
J Neuropsychiatry Clin Neurosci. 1993 Winter;5(1):61-5. doi: 10.1176/jnp.5.1.61.
Cognitive performance was assessed in 107 psychiatric patients whose age exceeded 59 years and who did not carry the diagnosis of organic mental syndrome. In this sample, tardive dyskinesia (TD) was associated with greater impairment in each of the seven cognitive domains assessed. These data do not address the etiology of TD but raise questions regarding the use of antipsychotics in young patients with cognitive impairment. Insofar as TD is an expression of basal ganglia dysfunction, these data also emphasize the critical role of relatively caudal brain structures in cognition and emotional expression.
对107名年龄超过59岁且未被诊断为器质性精神综合征的精神病患者进行了认知功能评估。在这个样本中，迟发性运动障碍（TD）与所评估的七个认知领域中的每一个领域的更大损害相关。这些数据并未涉及TD的病因，但引发了关于在有认知障碍的年轻患者中使用抗精神病药物的问题。鉴于TD是基底神经节功能障碍的一种表现，这些数据也强调了相对靠后的脑结构在认知和情感表达中的关键作用。
