Wade J B, Hart R P, Dougherty L M
Department of Psychiatry, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298-0268.
Brain Cogn. 1993 Sep;23(1):71-80. doi: 10.1006/brcg.1993.1045.
This study was undertaken to clarify factors associated with severity of tardive dyskinesia (TD). It was hypothesized that dopaminergic changes associated with neuroleptic medication may interact with unknown vulnerabilities contributing to the manifestation of TD. Fifty-four psychiatric patients residing on the acute and intermediate care wards of a Veterans Administration hospital participated. Thirty schizophrenic and 24 manic patients, under 60 years of age, were assessed for TD using the Abnormal Involuntary Movement Scale. Cognitive tests were used to form verbal and nonverbal composite indices. The results of multiple regression analyses revealed a modest linear relationship between TD and nonverbal function (p < .03) after controlling for duration of hospitalization, years of illness, motor speed, and age. This relationship was noted for both manic and schizophrenic patients. The results of this study suggest that nonverbal dysfunction is related to severity of TD.
本研究旨在阐明与迟发性运动障碍（TD）严重程度相关的因素。研究假设，与抗精神病药物相关的多巴胺能变化可能与导致TD表现的未知易感性相互作用。54名居住在退伍军人管理局医院急性和中级护理病房的精神病患者参与了研究。对30名年龄在60岁以下的精神分裂症患者和24名躁狂症患者，使用异常不自主运动量表评估TD。认知测试用于形成言语和非言语综合指数。多元回归分析结果显示，在控制住院时间、患病年限、运动速度和年龄后，TD与非言语功能之间存在适度的线性关系（p < 0.03）。躁狂症和精神分裂症患者均呈现这种关系。本研究结果表明，非言语功能障碍与TD的严重程度相关。
