Quesnel A, Pozzetto B, Moja P, Grattard F, Lucht F R, Touraine J L, Gaudin O G, Genin C
Department of Immunology, Faculty of Medicine Jacques Lisfranc, Saint-Etienne, France.
Clin Exp Immunol. 1993 Feb;91(2):237-40. doi: 10.1111/j.1365-2249.1993.tb05889.x.
Serum specimens from 66 HIV-1-infected subjects were tested by ELISA for the presence of IgA antibodies to HIV-1: 44 samples were found positive and 37 were confirmed by immunoblot. In these subjects, the presence of anti-HIV IgA antibodies was studied in relation to the total count of circulating CD4+ lymphocytes and to the level of serum IgA. A significative correlation (P < 0.03) was found between the absence of IgA to the subunit p68 of the reverse transcriptase and a count of CD4+ cell < 400/mm3 or total IgA level over 4.25 g/l. The same pattern was observed for the IgA antibodies to the p52 subunit but the association was just not significant (P < 0.07). No significant decrease was noted for the IgA directed towards the other proteins of HIV-1, especially the products of the gag gene.
用酶联免疫吸附测定法（ELISA）检测了66名HIV-1感染受试者的血清样本中抗HIV-1 IgA抗体的存在情况：44份样本呈阳性，37份经免疫印迹法确认。在这些受试者中，研究了抗HIV IgA抗体的存在与循环CD4+淋巴细胞总数以及血清IgA水平的关系。发现逆转录酶亚基p68的IgA缺失与CD4+细胞计数<400/mm3或总IgA水平超过4.25 g/l之间存在显著相关性（P<0.03）。针对p52亚基的IgA抗体也观察到相同模式，但这种关联不显著（P<0.07）。针对HIV-1其他蛋白（尤其是gag基因产物）的IgA未发现显著下降。
