嗜盐古菌小质粒的异质性

Akhmanova A S, Kagramanova V K, Mankin A S

Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, Russia.

J Bacteriol. 1993 Feb;175(4):1081-6. doi: 10.1128/jb.175.4.1081-1086.1993.

Small multicopy plasmids in three strains of halophilic archaea, SB3, GRB, and GN101, were found to be present in a cell as a population of related but not identical sequences. Two types of heterogeneity were observed: macroheterogeneity, represented by two major plasmid sequence versions homologous to each other by 80%, and microheterogeneity, in which individual plasmids differ by one or a few nucleotide substitutions.

在嗜盐古菌的三个菌株SB3、GRB和GN101中发现，小多拷贝质粒在细胞中以一组相关但不相同的序列形式存在。观察到两种类型的异质性：宏观异质性，由两个主要质粒序列版本代表，它们彼此同源性为80%；微观异质性，其中单个质粒因一个或几个核苷酸取代而有所不同。