Kruesi M J, Swedo S, Leonard H, Rubinow D R, Rapoport J L
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892.
Psychiatry Res. 1990 Sep;33(3):277-84. doi: 10.1016/0165-1781(90)90044-6.
Disruptive behavior disorders and obsessive-compulsive disorder have been associated with serotonergic dysfunction as well as particular body habitus findings in pediatric patients. Somatostatin, a peptide which stimulates serotonin release and inhibits growth hormone release, was measured in the cerebrospinal fluid (CSF) of 10 children with disruptive behavior disorders and in 10 age-, sex-, and race-matched pairs of obsessive-compulsive disorder patients. Decreased concentrations of somatostatin were found in disruptive behavior disorder patients relative to obsessive-compulsive children, even after controlling for differences in Tanner stage. In contrast to studies in adults, those patients in a depressed state did not have lower CSF somatostatin concentration.
破坏性行为障碍和强迫症与血清素功能障碍以及儿科患者特定的身体体型特征有关。生长抑素是一种刺激血清素释放并抑制生长激素释放的肽，在10名患有破坏性行为障碍的儿童以及10对年龄、性别和种族匹配的强迫症患者的脑脊液（CSF）中进行了测量。相对于强迫症儿童，破坏性行为障碍患者的生长抑素浓度降低，即使在控制了坦纳分期的差异之后也是如此。与成人研究不同的是，处于抑郁状态的患者脑脊液生长抑素浓度并没有降低。
