Hnatowich D J
J Nucl Med. 1975 Aug;16(8):764-8.
Gallium-68 (T 1/2 68 min) is a convenient label for radiopharmaceuticals designed for use with positron detection devices; the radionuclide is a generator produce obtained from its parent 68Ge (T 1/2 287 days). The labeling procedure itself is simple since gallium forms complexes without the use of reducing agents. However, 68Ga is present in the generator eluant as the gallium-EDTA chelate and must be separated from EDTA prior to its use as a label. A rapid and efficient method for achieving this separation and for preparing 68Ga-labeled compounds for human use has been developed. Paper chromatography is employed to determine the amount of each major gallium species present in preparations of two gallium complexes; 68Ga-adenosine triphosphate and 68Ga-citrate.
镓 -68（半衰期68分钟）是用于正电子检测设备的放射性药物的一种便捷标记物；该放射性核素是由其母体68锗（半衰期287天）产生的发生器产物。标记过程本身很简单，因为镓无需使用还原剂就能形成络合物。然而，68镓在发生器洗脱液中以镓 - 乙二胺四乙酸螯合物的形式存在，在用作标记物之前必须与乙二胺四乙酸分离。现已开发出一种快速有效的方法来实现这种分离，并制备供人类使用的68镓标记化合物。采用纸色谱法测定两种镓络合物制剂中各主要镓物种的含量；68镓 - 三磷酸腺苷和68镓 - 柠檬酸盐。
