Godfrey K M, Barker D J
MRC Environmental Epidemiology Unit (University of Southampton), Southampton General Hospital, UK.
Eur J Obstet Gynecol Reprod Biol. 1995 Jul;61(1):15-22. doi: 10.1016/0028-2243(95)02148-l.
Babies who are small or disproportionate at birth, or who have altered placental growth are now known to be at an increased risk of developing coronary heart disease, hypertension and diabetes during adult life. This has led to the suggestion that these diseases are 'programmed' by an inadequate supply of nutrients to the developing fetus. The phenomenon of 'programming', whereby undernutrition in early life permanently changes body structure and function, is well documented in animals. As yet, relatively little is known about the maternal influences that alter fetal and placental growth, and underlie the programming of adult cardiovascular disease during fetal development. There are, however, interesting indications that maternal nutrition may be important.
现在已知出生时体型小或比例失调，或胎盘生长异常的婴儿，在成年后患冠心病、高血压和糖尿病的风险会增加。这引发了一种观点，即这些疾病是由于发育中的胎儿营养供应不足而“编程”所致。“编程”现象，即生命早期的营养不良会永久性地改变身体结构和功能，在动物身上已有充分记录。然而，对于改变胎儿和胎盘生长并构成胎儿发育期间成人心血管疾病“编程”基础的母体影响，我们所知相对较少。不过，有一些有趣的迹象表明母体营养可能很重要。
