Orhue A A
Department of Obstetrics and Gynaecology, College of Medical Sciences, University of Benin, Nigeria.
Int J Gynaecol Obstet. 1993 Mar;40(3):219-25. doi: 10.1016/0020-7292(93)90834-j.
To investigate in women of low parity (para 1, 2 or 3) whether induction of labor using a regimen of intravenous oxytocin, increasing incrementally at 30-min intervals is safer than one increasing at 15-min intervals.
Two hundred and forty-five women of low parity requiring induction of labor by infusion of oxytocin were randomly allocated to incremental increases at 30-min intervals (123 women) as experimental group or 15-min intervals (122 women) as the control group. In both groups forewater amniotomy was performed synchronously with oxytocin infusion using the allocated regimen.
The 30-min incremental regimen resulted in less precipitate labor, uterine hyperstimulation and a reduced length of stay in hospital. The induction delivery interval was longer with the experimental group which also had less occurrence of postpartum hemorrhage, perineal tears and puerperal pyrexia.
Oxytocin infusion regimen with 30 min incremental increases is safer than the regimen with 15-min incremental increases.
在低产次（产次为1、2或3次）女性中研究，采用静脉滴注缩宫素方案且每30分钟递增剂量引产是否比每15分钟递增剂量更安全。
245名需要通过滴注缩宫素引产的低产次女性被随机分为两组，试验组123名女性采用每30分钟递增剂量的方案，对照组122名女性采用每15分钟递增剂量的方案。两组均在使用分配的方案静脉滴注缩宫素的同时同步进行人工破膜。
每30分钟递增剂量的方案导致急产、子宫过度刺激减少，住院时间缩短。试验组引产至分娩间隔时间更长，且产后出血、会阴撕裂和产褥热的发生率也更低。
每30分钟递增剂量的缩宫素滴注方案比每15分钟递增剂量的方案更安全。
