Cléandre D, Dufour P, Tiberghien B, Bernardi C, Vinatier D, Monnier J C
Service de Gynécologie-Obstétrique, CHU, Lille.
J Gynecol Obstet Biol Reprod (Paris). 1993;22(1):59-65.
The authors having studied retrospectively 23 pregnancies that were complicated by haemorrhagic proctocolitis or Crohn's disease, try to define by following the literature as well, how these diseases react on fertility and on pregnancy, and how pregnancy reacts on the diseases and the treatments that are available during pregnancy. As far as we know at present, the patients are sub-fertile in cases on ulcerative colitis and normally fertile in cases of Crohn's disease. These illnesses are not exacerbated by pregnancy, but pregnancies are affected by flare-ups of the condition, and therefore should be planned if possible for when the illness is in remission. Previous bowel resection does not alter the course of the pregnancy nor change the methods of delivery. These is no abnormal effect on the fetus or infant due to the treatment, but it is wiser to avoid using Azathioprine during embryogenesis.
作者回顾性研究了23例并发出血性直肠结肠炎或克罗恩病的妊娠病例,同时也参考相关文献,试图明确这些疾病对生育能力和妊娠的影响,以及妊娠对这些疾病和孕期可用治疗方法的影响。就目前所知,溃疡性结肠炎患者生育能力低下,而克罗恩病患者生育能力正常。这些疾病不会因妊娠而加重,但妊娠会受到病情发作的影响,因此如有可能,应在病情缓解时计划妊娠。既往肠道切除术不会改变妊娠进程,也不会改变分娩方式。治疗对胎儿或婴儿没有异常影响,但在胚胎形成期避免使用硫唑嘌呤更为明智。